USTUR WHOLE-BODY CASE 0212: 17-YEAR FOLLOW-UP OF PLUTONIUM CONTAMINATED WOUND
Open Access
- 7 July 2017
- journal article
- research article
- Published by Oxford University Press (OUP) in Radiation Protection Dosimetry
- Vol. 178 (2), 160-169
- https://doi.org/10.1093/rpd/ncx092
Abstract
The National Council of Radiation Protection and Measurements’ (NCRP) wound model was applied to the bioassay data from a United States Transuranium and Uranium Registries’ whole-body tissue donor, Case 0212. This individual was exposed to plutonium nitrate as a result of an occupational wound injury and he underwent extensive chelation treatment with Ca-DTPA. All major soft tissues and bones were collected post-mortem and radiochemically analyzed for 238Pu, 239,240Pu and 241Am. The 239,240Pu activity in the total body was estimated to be 232.0 Bq, with 80.3 Bq retained in the liver, 115.1 Bq in the skeleton and 14.3 Bq in the wound. The maximum likelihood method was used to simultaneously fit the ‘post-treatment’ urinary excretion and post-mortem liver and skeleton retention data. It was demonstrated that the deposited material was predominantly a strongly retained soluble compound (nitrate) with a 22% fraction of plutonium particles. The residual intake, the amount of plutonium deposited in the wound that was not removed from the system by Ca-DTPA, was estimated to be 288 Bq. The resulting committed effective dose was 134 mSv. Accounting for plutonium eliminated in the urine during chelation therapy, the actual ‘untreated’ intake was 1204 Bq, and the projected committed effective dose was 567 mSv. Hence, DTPA treatment reduced the dose by a factor of 4.Keywords
Funding Information
- U.S. Department of Energy (DE-HS0000073)
- Coordination for the Improvement of Higher Level Personnel (CAPES, Brazil) (013 355/2013-09)
This publication has 19 references indexed in Scilit:
- Modelling of bioassay data from a Pu wound treated by repeated DTPA perfusions: biokinetics and dosimetric approachesRadiation Protection Dosimetry, 2007
- APPLICATION OF MULTI-COMPARTMENT WOUND MODELS TO PLUTONIUM-CONTAMINATED WOUNDS INCURRED BY FORMER WORKERS AT ROCKY FLATSHealth Physics, 2006
- An analysis of a puncture wound case with medical interventionRadiation Protection Dosimetry, 2003
- 1976 Hanford Americium Exposure IncidentHealth Physics, 1983
- Plutonium Contaminated Wound Experience and Assay Techniques at the Los Alamos Scientific LaboratoryHealth Physics, 1974
- Assessment and Management of a Plutonium Contaminated Wound CaseHealth Physics, 1974
- Distribution of Plutonium and Americium in the Body 5 Years After an Exposure Via Contaminated Punctured WoundHealth Physics, 1972
- Observed Effects of Plutonium in Wounds Over a Long Period of TimeHealth Physics, 1964
- Absorption and measurement of radionuclides in wounds and abrasionsClinical Radiology, 1964
- The Los Alamos Scientific Laboratoryʼs Experience With Plutonium in ManHealth Physics, 1962