Hemodynamic Effects of Intravenously Administered Sodium Citrate

Abstract

MARKED elevations of serum citrate have been reported to occur in man during multiple rapid transfusions of citrated blood.^{1 2 3} The possibility of harmful effects is well recognized but often discounted.^{2 , 4} In an attempt to separate the circulatory effects of citrate from many other potentially adverse effects of massive transfusion, we have studied the hemodynamic effects of intravenous infusions of sodium citrate in normal, lightly anesthetized man and in the dog.MethodsClinical MaterialSix patients, 5 females and 1 male, were studied. Their ages were thirty-one to forty-four, with an average of thirty-eight years. All were undergoing ligation and stripping . . .