Neurotrophins and their Receptors in the Adult Hypo- and Hyperthyroid Rat after Kainic Acid Injection: anIn SituHybridization Study
- 1 September 1996
- journal article
- Published by Wiley in European Journal of Neuroscience
- Vol. 8 (9), 1873-1881
- https://doi.org/10.1111/j.1460-9568.1996.tb01331.x
Abstract
Thyroid hormone plays a key role in trophic events during development of the central nervous system. In spite of neurological and psychiatric symptoms associated with adult hypothyroidism, the role of thyroid hormone in mature brain function is less clear. In this paper we investigated the effect of thyroid status on kainic acid-induced up-regulation of mRNAs for members of the nerve growth factor family and related receptors in adult male rats by means of in situ hybridization. We found that in hypothyroid rats there is a dramatic attenuation of the kainic acid-induced up-regulation of mRNA levels for nerve growth factor, brain-derived neurotrophic factor and tyrosine kinase trkB in euthyroid rats. A trend to reduced c-fos mRNA up-regulation, which did not reach significance, was also found, whereas the increase in c-jun mRNA after kainic acid was similar in eu-, hypo- and hyperthyroid rats. These data indicate a severe impairment of the regulation of neurotrophin synthesis after excitotoxin administration in the hippocampus during adult hypothyroidism. Possible roles of thyroid hormone in molecular, biochemical and metabolic mechanisms of this defect are discussed.Keywords
This publication has 55 references indexed in Scilit:
- Functional Interactions of Neurotrophins and Neurotrophin ReceptorsAnnual Review of Neuroscience, 1995
- Expression of neurotrophins and the trk family of neurotrophin receptors in normal and hypothyroid rat brainMolecular Brain Research, 1994
- Regulation of neurotrophin and traka, trkb and trkc tyrosine kinase receptor messenger RNA expression in kindlingNeuroscience, 1993
- Spatial and temporal expression of alpha- and beta-thyroid hormone receptor mRNAs, including the beta 2-subtype, in the developing mammalian nervous systemJournal of Neuroscience, 1992
- Thyroid hormones precociously increase nerve growth factor gene expression in the submandibular gland of neonatal miceEndocrinology, 1992
- Thyroid Hormone Promotes Transient Nerve Growth Factor Synthesis in Rat Cerebellar NeuroblastsDevelopmental Neuroscience, 1992
- Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brainExperimental Neurology, 1991
- Splicing of juvenile and adult tau mRNA variants is regulated by thyroid hormone.Proceedings of the National Academy of Sciences of the United States of America, 1991
- Expression of erbAα and β mRNAs in regions of adult rat brainMolecular and Cellular Endocrinology, 1990
- An Interaction Between Thyroid Hormone and Nerve Growth Factor Promotes the Development of Hippocampus, Olfactory Bulbs and Cerebellum: a Comparative Biochemical Study of Normal and Hypothyroid RatsGrowth Factors, 1990