Trophoblast development
Open Access
- 1 March 2012
- journal article
- review article
- Published by Bioscientifica in Reproduction
- Vol. 143 (3), 231-246
- https://doi.org/10.1530/rep-11-0374
Abstract
This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies,in vivoloss-of-function models andin vitrosystems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene regulatory networks. While trophoblast differentiation is quite distinct between cattle and mice, as would be expected from their different modes of implantation, recent studies have demonstrated that differences arise much earlier during trophoblast development.Keywords
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