Correlation between High-Resolution Computed Tomography Findings and Lung Function in Pulmonary Langerhans Cell Histiocytosis
- 3 August 2007
- journal article
- research article
- Published by S. Karger AG in Respiration
- Vol. 74 (6), 640-646
- https://doi.org/10.1159/000106843
Abstract
Pulmonary Langerhans cell histiocytosis (PLCH) is an uncommon interstitial lung disease which can lead to serious respiratory failure. The correlation between high-resolution computed tomography (HRCT) findings and lung function have not been studied in depth. To assess the relationship between HRCT findings and lung function in PLCH. Since HRCT abnormalities in PLCH consist mainly of nodular opacities and cystic abnormalities, we determined semiquantitative scores of nodular profusion and cystic extent. We therefore assessed the relationship between HRCT abnormalities on one hand and lung function and gas exchange parameters on the other, in patients with PLCH. In our series of 26 consecutive patients, we found no significant correlation between the score of nodular profusion and lung function or gas exchange parameters. The score of cystic extent showed a quite strong and significant correlation with FEV(1)/FVC (r = -0.62; p = 0.01), but also with PaO(2) (r = -0.69; p = 0.001) and carbon monoxide diffusing capacity (r = -0.60; p < 0.01). Furthermore, the patients with a predominant cystic pattern (n = 7) had the highest grade of dyspnea on exertion (p = 0.004), the lowest FEV(1)/FVC ratio (p = 0.02) and the lowest PaO(2) (p = 0.02) compared to patients with a predominant nodular (n = 12) or a mixed pattern (n = 7). We conclude that in PLCH, the cystic extent on HRCT, but not the nodular profusion, correlates significantly with lung function abnormalities and impairment of gas exchange.Keywords
This publication has 16 references indexed in Scilit:
- Do High-Resolution CT Findings of Usual Interstitial Pneumonitis Obviate Lung Biopsy?Respiration, 2005
- Diffuse Cystic Lung DiseasesChest, 2004
- Three-Dimensional Characterization of Pathologic Lesions in Pulmonary Langerhans Cell HistiocytosisAmerican Journal of Respiratory and Critical Care Medicine, 2002
- Clinical Outcomes of Pulmonary Langerhans'-Cell Histiocytosis in AdultsNew England Journal of Medicine, 2002
- Is High-Resolution Computed Tomography a Reliable Tool to Predict the Histopathological Activity of Pulmonary Langerhans Cell Histiocytosis?American Journal of Respiratory and Critical Care Medicine, 2000
- Accuracy of high-resolution CT in diagnosing lung diseases.American Journal of Roentgenology, 1998
- Determinants of survival in pulmonary Langerhans' cell granulomatosis (histiocytosis X). Groupe d'Etude en Pathologie Interstitielle de la Societe de Pathologie Thoracique du NordEuropean Respiratory Journal, 1996
- Pulmonary histiocytosis X: pulmonary function and exercise pathophysiology.American Journal of Respiratory and Critical Care Medicine, 1996
- Clinical and Radiologic Features, Lung Function and Therapeutic Results in Pulmonary Histiocytosis XRespiration, 1993
- Application of ultrastructural morphometry to lung biopsy specimens in pulmonary histiocytosis X.Thorax, 1975