Papillary Thyroid Cancer Treated at the Mayo Clinic, 1946 Through 1970: Initial Manifestations, Pathologic Findings, Therapy, and Outcome

Abstract
Although thyroid cancer is the most frequently diagnosed endocrine malignant lesion, it is not a common disease. In the United States during 1986, an estimated 10,600 new cases will be diagnosed and 1,100 deaths from thyroid cancer will occur.1 x 1 Silverberg, E and Lubera, J. Cancer statistics, 1986. CA. 1986; 36: 9–25 Crossref | Google Scholar See all References In most patients with thyroid cancer described in the literature, the tumors have been well differentiated. In North American reports of malignant thyroid tumors, papillary carcinoma (including mixed papillary and follicular carcinoma) has accounted for 52 to 81% of all cases.2 x 2 Hirabayashi, RN and Lindsay, S. Carcinoma of the thyroid gland: a statistical study of 390 patients. J Clin Endocrinol Metab. 1961; 21: 1596–1610 Crossref | PubMed | Scopus (80) | Google Scholar See all References , 3 x 3 Woolner, LB. Thyroid carcinoma: pathologic classification with data on prognosis. Semin Nucl Med. 1971; 1: 481–502 Abstract | Full Text PDF | PubMed | Scopus (139) | Google Scholar See all References , 4 x 4 Mazzaferri, EL and Young, RL. Papillary thyroid carcinoma: a 10 year follow-up report of the impact of therapy in 576 patients. Am J Med. 1981; 70: 511–518 Abstract | Full Text PDF | PubMed | Scopus (515) | Google Scholar See all References , 5 x 5 Samaan, NA, Maheshwari, YK, Nader, S, Hill, CS Jr, Schultz, PN, Haynie, TP, Hickey, RC, Clark, RL, Goepfert, H, Ibanez, ML, and Litton, CE. Impact of therapy for differentiated carcinoma of the thyroid: an analysis of 706 cases. J Clin Endocrinol Metab. 1983; 56: 1131–1138 Crossref | PubMed | Scopus (224) | Google Scholar See all References , 6 x 6 Rossi, RL, Nieroda, C, Cady, B, and Wool, MS. Malignancies of the thyroid gland: the Lahey Clinic experience. Surg Clin North Am. 1985; 65: 211–230 Crossref | PubMed | Scopus (37) | Google Scholar See all References , 7 x 7 Simpson, WJ and McKinney, SE. Canadian survey of thyroid cancer. Can Med Assoc J. 1985; 132: 925–931 PubMed | Google Scholar See all References