MicroRNA and cancer
Top Cited Papers
Open Access
- 9 October 2012
- journal article
- review article
- Published by Wiley in Molecular Oncology
- Vol. 6 (6), 590-610
- https://doi.org/10.1016/j.molonc.2012.09.006
Abstract
With the advent of next generation sequencing techniques a previously unknown world of non‐coding RNA molecules have been discovered. Non‐coding RNA transcripts likely outnumber the group of protein coding sequences and hold promise of many new discoveries and mechanistic explanations for essential biological phenomena and pathologies. The best characterized non‐coding RNA family consists in humans of about 1400 microRNAs for which abundant evidence have demonstrated fundamental importance in normal development, differentiation, growth control and in human diseases such as cancer. In this review, we summarize the current knowledge and concepts concerning the involvement of microRNAs in cancer, which have emerged from the study of cell culture and animal model systems, including the regulation of key cancer‐related pathways, such as cell cycle control and the DNA damage response. Importantly, microRNA molecules are already entering the clinic as diagnostic and prognostic biomarkers for patient stratification and also as therapeutic targets and agents.Keywords
Funding Information
- Danish National Research Foundation
- Danish National Advanced Technology Foundation
- Novo Nordisk Foundation
- EC FP7 programs (ONCOMIRS (201102)
- Lundbeck Foundation
- Danish Cancer Society
This publication has 161 references indexed in Scilit:
- Circulating MicroRNAs as Noninvasive Biomarkers in Breast CancerPublished by Springer Science and Business Media LLC ,2012
- MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive reviewEMBO Molecular Medicine, 2012
- Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma DevelopmentCancer Cell, 2010
- Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21Cancer Cell, 2010
- miR-155 gene: A typical multifunctional microRNABiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
- Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer ModelCell, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial CellsCancer Cell, 2008
- Epigenetic inactivation of microRNA gene hsa‐mir‐9‐1 in human breast cancerThe Journal of Pathology, 2007
- Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA TargetsCell, 2005