In order to understand the sanitation condition of drinking water in the rural areas of High-tech District in Tai’an City, and to provide scientific bases for drinking water quality improvement and public health protection, water quality was tested and analyzed using the methods recommended in the China national health standard GB5750-85, which included 14 indicators, i.e. sensory characteristics, general chemical indicators, toxicological indicators and bacteriological indicators. The results showed that the contents of total coliform, ammonia nitrogen and iron exceeded the standards, and the contents of volatile phenol and Cr (VI), and the total hardness slightly exceeded the standards. It was concluded that drinking water, especially well water in the rural areas of High-tech District in Tai’an City was slightly polluted. Therefore, currently the related government departments should focus on strengthening “the three wastes” treatment and sanitation management of drinking water transmission, and providing additional water disinfection facilities.