Endiandrin A, a Potent Glucocorticoid Receptor Binder Isolated from the Australian Plant Endiandra anthropophagorum
- 21 June 2007
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 70 (7), 1118-1121
- https://doi.org/10.1021/np070073x
Abstract
Bioassay-guided fractionation of the DCM extract from the roots of Endiandra anthropophagorum resulted in the isolation of a new cyclobutane lignan, endiandrin A (1), together with the known natural products nectandrin B (2) and (−)-dihydroguaiaretic acid (3). The structure of 1 was determined by extensive 1D and 2D NMR and MS data analyses. Acetylation and methylation of 1 yielded di-O-acetylendiandrin A (4) and di-O-methylendiandrin A (5), respectively. All compounds were tested in a glucocorticoid receptor binding assay and displayed IC50 values ranging from 0.9 to 35 μM.Keywords
This publication has 9 references indexed in Scilit:
- Glucocorticoid receptors in human airwaysAllergy, 2004
- A New Cyclobutane Lignan fromCinnamomum balansaeNatural Product Letters, 2001
- Dihydroguaiaretic Acid: A Bioactive Component of the Stem Bark ofPycnanthus angolensisPlanta Medica, 1997
- Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to GlucocorticoidsEndocrine Reviews, 1996
- Reassignment of structures of the neolignans, magnosalin and andamanicinPhytochemistry, 1993
- A neolignan from Piper sumatranumPhytochemistry, 1990
- New heterodifunctional ligands for organotransition-metal chemistry: Ph2P(CH2)nC5Me4H(n = 0,2)The Journal of Organic Chemistry, 1990
- Cleomiscosin D, a coumarino-lignan from seeds of Cleome viscosaPhytochemistry, 1988
- Antitumor Plants. X. Constituents of Nectandra rigidaJournal of Natural Products, 1980