Uncommon Types of Lung Carcinoma With Mixed Histology: Sarcomatoid Carcinoma, Adenosquamous Carcinoma, and Mucoepidermoid Carcinoma
- 1 August 2018
- journal article
- research article
- Published by Archives of Pathology and Laboratory Medicine in Archives Of Pathology & Laboratory Medicine
- Vol. 142 (8), 914-921
- https://doi.org/10.5858/arpa.2017-0584-ra
Abstract
Context.-Lung tumors are histologically heterogeneous, but classification of lung carcinoma has prognostic impact and increasingly, specific molecular correlates. Objective.-To update the gross, microscopic, and molecular pathology of unusual lung carcinomas to assure accurate classification. In entities with mixed histology, the recognition of specific features or rare patterns is critical to diagnosis. These diagnoses can identify tumors with aggressive clinical behavior, and diagnostic pitfalls can therefore result in underdiagnosis of these already rare entities. Incorrect classification of more indolent tumors into the more aggressive categories can also occur. In the area of molecular pathology, these unusual tumors have a specific spectrum of molecular alterations. Data Sources.-PubMed searches for lung and sarcomatoid carcinoma, pleomorphic carcinoma, blastoma, carcinosarcoma, and adenosquamous and mucoepidermoid carcinoma were undertaken and this information was integrated with clinical experience of the author. Conclusions.-These uncommon carcinomas have specific clinicopathologic features, and attention to their gross and microscopic pathology leads to classification with important associated molecular findings.Keywords
This publication has 77 references indexed in Scilit:
- Therapeutic efficacy of gefitinib and erlotinib in patients with advanced lung adenosquamous carcinomaJournal of the Chinese Medical Association, 2013
- Response to Erlotinib in Patients with EGFR Mutant Advanced Non–Small Cell Lung Cancers with a Squamous or Squamous-like ComponentMolecular Cancer Therapeutics, 2012
- Clarifying the Spectrum of Driver Oncogene Mutations in Biomarker-Verified Squamous Carcinoma of Lung: Lack of EGFR/KRAS and Presence of PIK3CA/AKT1 MutationsClinical Cancer Research, 2012
- Pulmonary Pleomorphic Carcinoma: A Clinicopathological Study Including EGFR Mutation AnalysisJournal of Thoracic Oncology, 2010
- EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: Implications for anti‐EGFR treatment of a rare lung malignancyInternational Journal of Cancer, 2009
- Genetic Heterogeneity of EGFR Mutation in Pleomorphic Carcinoma of the Lung: Response to Gefitinib and Clinical OutcomeJapanese Journal of Clinical Oncology, 2009
- Epidermal Growth Factor Receptor Mutations and the Clinical Outcome in Male Smokers with Squamous Cell Carcinoma of LungJournal of Korean Medical Science, 2009
- Aberrant Nuclear/Cytoplasmic Localization and Gene Mutation of β-Catenin in Classic Pulmonary BlastomaThe American Journal of Surgical Pathology, 2004
- β‐Catenin mutations in pulmonary blastomas: association with morule formationThe Journal of Pathology, 2003
- Adenosquamous carcinoma of the lung: radiologic appearance.American Journal of Roentgenology, 1994