International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family
Top Cited Papers
- 17 August 2010
- journal article
- review article
- Published by American Society for Pharmacology & Experimental Therapeutics (ASPET) in Pharmacological Reviews
- Vol. 62 (3), 381-404
- https://doi.org/10.1124/pr.110.002725
Abstract
Transient receptor potential (TRP) channels are a large family of ion channel proteins, surpassed in number in mammals only by voltage-gated potassium channels. TRP channels are activated and regulated through strikingly diverse mechanisms, making them suitable candidates for cellular sensors. They respond to environmental stimuli such as temperature, pH, osmolarity, pheromones, taste, and plant compounds, and intracellular stimuli such as Ca2+ and phosphatidylinositol signal transduction pathways. However, it is still largely unknown how TRP channels are activated in vivo. Despite the uncertainties, emerging evidence using TRP channel knockout mice indicates that these channels have broad function in physiology. Here we review the recent progress on the physiology, pharmacology and pathophysiological function of mammalian TRP channels.Keywords
This publication has 179 references indexed in Scilit:
- TRPM5 regulates glucose-stimulated insulin secretionPflügers Archiv - European Journal of Physiology, 2010
- Mutations in TRPM1 Are a Common Cause of Complete Congenital Stationary Night BlindnessAmerican Journal of Human Genetics, 2009
- TRPM1 Is Mutated in Patients with Autosomal-Recessive Complete Congenital Stationary Night BlindnessAmerican Journal of Human Genetics, 2009
- Recessive Mutations of the Gene TRPM1 Abrogate ON Bipolar Cell Function and Cause Complete Congenital Stationary Night Blindness in HumansAmerican Journal of Human Genetics, 2009
- The puzzling role of TRPC3 channels in motor coordinationPflügers Archiv - European Journal of Physiology, 2009
- The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1Pflügers Archiv - European Journal of Physiology, 2009
- TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATPPflügers Archiv - European Journal of Physiology, 2009
- Mutations in the Gene Encoding the Calcium-Permeable Ion Channel TRPV4 Produce Spondylometaphyseal Dysplasia, Kozlowski Type and Metatropic DysplasiaAmerican Journal of Human Genetics, 2009
- Reduced Oral Ethanol Avoidance in Mice Lacking Transient Receptor Potential Channel Vanilloid Receptor 1Behavior Genetics, 2008
- TRPC5 channels undergo changes in gating properties during the activation-deactivation cycleJournal of Cellular Physiology, 2008