Antibiotic Consumption, Bacterial Resistance and their Correlation in a Swiss University Hospital and its Adult Intensive Care Units
- 1 December 2003
- journal article
- research article
- Published by Informa UK Limited in Scandinavian Journal of Infectious Diseases
- Vol. 35 (11), 843-850
- https://doi.org/10.1080/00365540310016646
Abstract
Ecological surveys of high-antibiotic use areas in the hospital should be used to evaluate patterns and trends in order to optimise antibiotic consumption and minimise resistance. We conducted a retrospective cohort study with the aim to examine trends in antimicrobial consumption and bacterial susceptibility at the Geneva University Hospital and its adult ICUs between 1996 and 2000. The average annual consumption of antimicrobials was 400 d-defined doses (DDD)/1000 patient-d in the entire hospital, 462 in the surgical ICU and 683 in the medical ICU. In the medical ICU, we observed a steady decrease of intravenous antimicrobial use, whereas a 25% increase in the total antimicrobial consumption was noted in 1999 and 2000 for the entire hospital. The proportion of different bacterial species, resistance rates and antibiotic consumption rates differed between the entire hospital and the ICUs, with moderate variation between y. Possible relationships between antibiotic consumption and resistance rates, expressed as DDD and as number of resistant isolates per 1000 patient-d respectively, were calculated for of the most frequently isolated bacteria (total 71 correlations). Statistically significant positive correlations between antibiotic consumption and resistance were found in Escherichia coli for piperacillin, in Pseudomonas aeruginosa for piperacillin, cephalosporins and aminoglycosides, in Klebsiella spp. for cephalosporin, in coagulase-negative staphylococci for gentamicin and in Streptococcus pneumoniae for penicillin.Keywords
This publication has 20 references indexed in Scilit:
- Parallel Analysis of Individual and Aggregated Data on Antibiotic Exposure and Resistance in Gram‐Negative BacilliClinical Infectious Diseases, 2001
- Impact of a Hospital‐Based Antimicrobial Management Program on Clinical and Economic OutcomesClinical Infectious Diseases, 2001
- Influence of an Infectious Disease Consulting Service on Quality and Costs of Antibiotic Prescriptions in a University HospitalScandinavian Journal of Infectious Diseases, 2001
- Assessment of the Relationship between Antimicrobial Usage and Susceptibility: Differences between the Hospital and Specific Patient-Care AreasClinical Infectious Diseases, 2000
- Impact of a prevention strategy targeted at vascular-access care on incidence of infections acquired in intensive careThe Lancet, 2000
- Antibiotic use in Dutch hospitals 1991–1996Journal of Antimicrobial Chemotherapy, 2000
- Use of antibiotics in patients receiving intensive careClinical Intensive Care, 1998
- Antibiotic Use in 3 European University HospitalsScandinavian Journal of Infectious Diseases, 1998
- Predominant pathogens found in the European prevalence of infection in intensive care studyEuropean Journal of Clinical Microbiology & Infectious Diseases, 1996
- Pseudomonas aeruginosa Outbreak in a Burn Unit: Role of Antimicrobials in the Emergence of Multiply Resistant StrainsThe Journal of Infectious Diseases, 1994