Rearrangement of c‐myc, pim‐1 and Mlvi‐1 and trisomy of chromosome 15 in MCF‐ and moloney‐MuLV‐induced murine T‐cell leukemias

Abstract

Provirus insertion near the c‐myc, pim‐1 or MIvi‐I genes occurred in 7 out of 59 virally induced T‐cell leukemias. C‐myc was exclusively rearranged in approximately 10% of MCF 247‐induced tumors while MIvi‐I was rearranged to a similar frequency in Molo‐ney‐virus‐induced lymphomas. Out of 25 karyotyped tumors, 9 (36%) showed trisomy of chromosome 15. Provirus insertion near c‐myc, pim‐I or MIvi‐I occurred both in diploid lymphomas and in tumors with trisomy 15. These results suggest that the molecular and cytogenetic changes observed in murine T‐cell leukemias are independent tumor‐associated events and that trisomy of chromosome 15 is a common tumor‐progression‐related event.