Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer
Open Access
- 7 January 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Breast Cancer Research
- Vol. 14 (1), R6
- https://doi.org/10.1186/bcr3087
Abstract
Overexpression of the oxygen-responsive transcription factor hypoxia-inducible factor 1α (HIF-1α) correlates with poor prognosis in breast cancer patients. The mouse mammary tumor virus polyoma virus middle T (MMTV-PyMT) mouse is a widely utilized preclinical mouse model that resembles human luminal breast cancer and is highly metastatic. Prior studies in which the PyMT model was used demonstrated that HIF-1α is essential to promoting carcinoma onset and lung metastasis, although no differences in primary tumor end point size were observed. Using a refined model system, we investigated whether HIF-1α is directly implicated in the regulation of tumor-initiating cells (TICs) in breast cancer.This publication has 79 references indexed in Scilit:
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