Reelin glycoprotein: structure, biology and roles in health and disease
Open Access
- 7 December 2004
- journal article
- review article
- Published by Springer Science and Business Media LLC in Molecular Psychiatry
- Vol. 10 (3), 251-257
- https://doi.org/10.1038/sj.mp.4001613
Abstract
Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Reln gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in neuropsychiatric disorders like autism or schizophrenia.This publication has 88 references indexed in Scilit:
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