Hepatocellular carcinoma: Advances in diagnosis, management, and long term outcome
Open Access
- 1 January 2015
- journal article
- review article
- Published by Baishideng Publishing Group Inc. in World Journal of Hepatology
- Vol. 7 (9), 1157-67
- https://doi.org/10.4254/wjh.v7.i9.1157
Abstract
Hepatocellular carcinoma (HCC) remains a common and lethal malignancy worldwide and arises in the setting of a host of diseases. The incidence continues to increase despite multiple vaccines and therapies for viruses such as the hepatitis B and C viruses. In addition, due to the growing incidence of obesity in Western society, there is anticipation that there will be a growing population with HCC due to non-alcoholic fatty liver disease. Due to the growing frequency of this disease, screening is recommended using ultrasound with further imaging using magnetic resonance imaging and multi-detector computed tomography used for further characterization of masses. Great advances have been made to help with the early diagnosis of small lesions leading to potential curative resection or transplantation. Resection and transplantation maybe used in a variety of patients that are carefully selected based on underlying liver disease. Using certain guidelines and clinical acumen patients may have good outcomes with either resection or transplantation however many patients are inoperable at time of presentation. Fortunately, the use of new locoregional therapies has made down staging patients a potential option making them potential surgical candidates. Despite a growing population with HCC, new advances in viral therapies, chemotherapeutics, and an expanding population of surgical and transplant candidates might all contribute to improved long-term survival of these patients.Keywords
This publication has 94 references indexed in Scilit:
- Liver Transplantation Versus Liver Resection in the Treatment of Hepatocellular CarcinomaTransplantation, 2014
- Contrast Material–induced Nephrotoxicity and Intravenous Low-Osmolality Iodinated Contrast Material: Risk Stratification by Using Estimated Glomerular Filtration RateRadiology, 2013
- Management of hepatocellular carcinoma: An updateHepatology, 2011
- Transcatheter Therapy for Hepatic Malignancy: Standardization of Terminology and Reporting CriteriaJournal of Vascular and Interventional Radiology, 2009
- Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosisHepatology, 2007
- Liver Transplantation Criteria For Hepatocellular Carcinoma Should Be ExpandedAnnals of Surgery, 2007
- Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stressBiological Chemistry, 2006
- Resection and Liver Transplantation for Hepatocellular CarcinomaSeminars in Liver Disease, 2005
- The Barcelona approach: Diagnosis, staging, and treatment of hepatocellular carcinomaLiver Transplantation, 2004
- Selection criteria for liver transplantation in early-stage hepatocellular carcinoma with cirrhosis: Results of a multicenter studyLiver Transplantation, 2001