Arguments for live flavivirus vaccines

Abstract
Stephen Seligman and Ernest Gould 1 Seligman SJ Gould EA Live flavivirus vaccines: reasons for caution. Lancet. 2004; 363 : 2073-2075 Summary Full Text Full Text PDF PubMed Scopus (92) Google Scholar state that the possibility of recombination between wild-type and vaccine virus strains is a drawback when using live vaccines. However, we believe that many flaviviruses identified as recombinants are artifacts created by errors in sequences deposited in public databases, and that the case for recombination has been overstated.

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