Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?
- 30 May 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 30 (38), 3985-4003
- https://doi.org/10.1038/onc.2011.167
Abstract
Mutations in cancer cells affecting subunits of the respiratory chain (RC) indicate a central role of oxidative phosphorylation for tumourigenesis. Recent studies have suggested that such mutations of RC complexes impact apoptosis induction. We review here the evidence for this hypothesis, which in particular emerged from work on how complex I and II mediate signals for apoptosis. Both protein aggregates are specifically inhibited for apoptosis induction through different means by exploiting with protease activation and pH change, two widespread but independent features of dying cells. Nevertheless, both converge on forming reactive oxygen species for the demise of the cell. Investigations into these mitochondrial processes will remain a rewarding area for unravelling the causes of tumourigenesis and for discovering interference options.This publication has 197 references indexed in Scilit:
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