Interrelation of Coronary Calcification, Myocardial Ischemia, and Outcomes in Patients With Intermediate Likelihood of Coronary Artery Disease
Top Cited Papers
- 1 April 2008
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 117 (13), 1693-1700
- https://doi.org/10.1161/circulationaha.107.717512
Abstract
Background— Although the value of coronary artery calcium (CAC) for atherosclerosis screening is gaining acceptance, its efficacy in predicting flow-limiting coronary artery disease remains controversial, and its incremental prognostic value over myocardial perfusion is not well established. Methods and Results— We evaluated 695 consecutive intermediate-risk patients undergoing combined rest-stress rubidium 82 positron emission tomography (PET) perfusion imaging and CAC scoring on a hybrid PET-computed tomography (CT) scanner. The frequency of abnormal scans among patients with a CAC score ≥400 was higher than that in patients with a CAC score of 1 to 399 (48.5% versus 21.7%, P P Conclusions— Although increasing CAC content is generally predictive of a higher likelihood of ischemia, its absence does not completely eliminate the possibility of flow-limiting coronary artery disease. Importantly, a stepwise increase occurs in the risk of adverse events with increasing CAC scores in patients with and without ischemia on PET myocardial perfusion imaging.Keywords
This publication has 30 references indexed in Scilit:
- New Technology for Noninvasive Evaluation of Coronary Artery DiseaseCirculation, 2007
- Relationship between stress-induced myocardial ischemia and atherosclerosis measured by coronary calcium tomographyJournal of the American College of Cardiology, 2004
- Electron-Beam Tomography Coronary Artery Calcium and Cardiac EventsCirculation, 2003
- Determinants of risk and its temporal variation in patients with normal stress myocardial perfusion scansJournal of the American College of Cardiology, 2003
- Adenosine myocardial perfusion single-photon emission computed tomography in women compared with menJournal of the American College of Cardiology, 2003
- Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and OpportunitiesNew England Journal of Medicine, 1997
- Apolipoproteins and ischaemic heart disease: implications for screeningThe Lancet, 1994
- Quantification of coronary artery calcium using ultrafast computed tomographyJournal of the American College of Cardiology, 1990
- Cholesterol and mortality. 30 years of follow-up from the Framingham studyPublished by American Medical Association (AMA) ,1987
- How well can we predict coronary heart disease? Findings in the United Kingdom Heart Disease Prevention Project.BMJ, 1984