Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination

Abstract
Serum neutralizing antibodies rapidly appear after SARS-CoV-2 infection1 and vaccination2 and are maintained for several months.3,4 The emergence of SARS-CoV-2 variants has raised concerns about the breadth of neutralizing-antibody responses. We compared the neutralizing-antibody response to 4 variants in infected and vaccinated individuals to determine how mutations within the spike protein are associated with virus neutralization.