Effects of a new nutraceutical substance on clinical and molecular parameters in patients with chronic venous ulceration
- 25 February 2014
- journal article
- research article
- Published by Wiley in International Wound Journal
- Vol. 13 (1), 88-96
- https://doi.org/10.1111/iwj.12240
Abstract
Pathophysiological events involved in the onset of chronic venous ulceration (CVU) are inflammation, activation of polymorphonucleates (PMNs) and secretion of proteases such as matrix metalloproteinases (MMPs), which degrade extracellular matrix (ECM) that is a support for vascular and tissutal wall. MMPs, neutrophil gelatinase‐associated lipocalin (NGAL) and inflammatory cytokines are overexpressed in CVUs and they could play a central role in pathophysiological mechanisms of skin lesion and delayed wound healing. Bioflavonoids, such as diosmin and other compounds, appear to have several provessel function activities including anti‐inflammatory, antioxidant and phlebotonic effects and are widely used in the treatment of chronic venous disease (CVD)‐related problems.Keywords
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