Laboratory Response to Ebola — West Africa and United States
- 8 July 2016
- journal article
- Published by Centers for Disease Control MMWR Office in MMWR Supplements
- Vol. 65 (3), 44-49
- https://doi.org/10.15585/mmwr.su6503a7
Abstract
The 2014-2016 Ebola virus disease (Ebola) epidemic in West Africa highlighted the need to maintain organized laboratory systems or networks that can be effectively reorganized to implement new diagnostic strategies and laboratory services in response to large-scale events. Although previous Ebola outbreaks enabled establishment of critical laboratory practice safeguards and diagnostic procedures, this Ebola outbreak in West Africa highlighted the need for planning and preparedness activities that are better adapted to emerging pathogens or to pathogens that have attracted little commercial interest. The crisis underscored the need for better mechanisms to streamline development and evaluation of new diagnostic assays, transfer of material and specimens between countries and organizations, and improved processes for rapidly deploying health workers with specific laboratory expertise. The challenges and events of the outbreak forced laboratorians to examine not only the comprehensive capacities of existing national laboratory systems to recognize and respond to events, but also their sustainability over time and the mechanisms that need to be pre-established to ensure effective response. Critical to this assessment was the recognition of how response activities (i.e., infrastructure support, logistics, and workforce supplementation) can be used or repurposed to support the strengthening of national laboratory systems during the postevent transition to capacity building and recovery. This report compares CDC's domestic and international laboratory response engagements and lessons learned that can improve future responses in support of the International Health Regulations and Global Health Security Agenda initiatives.The activities summarized in this report would not have been possible without collaboration with many U.S. and international partners (http://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/partners.html).Keywords
This publication has 6 references indexed in Scilit:
- Early Identification and Prevention of the Spread of Ebola — United StatesMMWR Supplements, 2016
- Ebola Virus Diagnostics: The US Centers for Disease Control and Prevention Laboratory in Sierra Leone, August 2014 to March 2015The Journal of Infectious Diseases, 2015
- High‐Throughput Molecular Detection of Hemorrhagic Fever Virus Threats with Applications for Outbreak SettingsThe Journal of Infectious Diseases, 2007
- Marburgvirus Genomics and Association with a Large Hemorrhagic Fever Outbreak in AngolaJournal of Virology, 2006
- Rapid Diagnosis of Ebola Hemorrhagic Fever by Reverse Transcription-PCR in an Outbreak Setting and Assessment of Patient Viral Load as a Predictor of OutcomeJournal of Virology, 2004
- An Introduction to Ebola: The Virus and the DiseaseThe Journal of Infectious Diseases, 1999