MicroRNA-21 Regulates the Proliferation and Invasion in Esophageal Squamous Cell Carcinoma
Open Access
- 15 March 2009
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 15 (6), 1915-1922
- https://doi.org/10.1158/1078-0432.ccr-08-2545
Abstract
Purpose: MicroRNAs are ∼22 nucleotide noncoding RNA molecules that posttranscriptionally regulate gene expression. The aim of this study was (a) to determine a role of microRNA-21 in esophageal squamous cell carcinoma and (b) to elucidate the regulation of the programmed cell death 4 (PDCD4) gene by microRNA-21.Keywords
This publication has 45 references indexed in Scilit:
- MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon AdenocarcinomaJAMA, 2008
- MicroRNA expression profiles of esophageal cancerThe Journal of Thoracic and Cardiovascular Surgery, 2008
- MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular CancerGastroenterology, 2007
- Microrna expression distinguishes between germinal center B cell‐like and activated B cell‐like subtypes of diffuse large B cell lymphomaInternational Journal of Cancer, 2007
- Altered Expression of miR-21, miR-31, miR-143 and miR-145 Is Related to Clinicopathologic Features of Colorectal CancerOncology, 2007
- Oncomirs — microRNAs with a role in cancerNature Reviews Cancer, 2006
- In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probesNature Methods, 2005
- Silencing of microRNAs in vivo with ‘antagomirs’Nature, 2005
- MicroRNAs Modulate Hematopoietic Lineage DifferentiationScience, 2004
- A new mathematical model for relative quantification in real-time RT-PCRNucleic Acids Research, 2001