Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC)
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Open Access
- 22 February 2009
- Vol. 64 (6), 476-483
- https://doi.org/10.1136/thx.2008.106609
Abstract
Background: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global prevalence and severity of asthma symptoms in children. Methods: A cross-sectional questionnaire survey of 798 685 children aged 13–14 years from 233 centres in 97 countries, and 388 811 children aged 6–7 years from 144 centres in 61 countries, was conducted between 2000 and 2003 in >90% of the centres. Results: The prevalence of wheeze in the past 12 months (current wheeze) ranged from 0.8% in Tibet (China) to 32.6% in Wellington (New Zealand) in the 13–14 year olds, and from 2.4% in Jodhpur (India) to 37.6% in Costa Rica in the 6–7 year olds. The prevalence of symptoms of severe asthma, defined as ⩾4 attacks of wheeze or ⩾1 night per week sleep disturbance from wheeze or wheeze affecting speech in the past 12 months, ranged from 0.1% in Pune (India) to 16% in Costa Rica in the 13–14 year olds and from 0% to 20.3% in the same two centres, respectively, in the 6–7 year olds. Ecological economic analyses revealed a significant trend towards a higher prevalence of current wheeze in centres in higher income countries in both age groups, but this trend was reversed for the prevalence of severe symptoms among current wheezers, especially in the older age group. Conclusion: Wide variations exist in the symptom prevalence of childhood asthma worldwide. Although asthma symptoms tend to be more prevalent in more affluent countries, they appear to be more severe in less affluent countries.This publication has 13 references indexed in Scilit:
- International correlations between indicators of prevalence, hospital admissions and mortality for asthma in childrenInternational Journal of Epidemiology, 2008
- Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC)Thorax, 2007
- Parental understanding of wheeze and its impact on asthma prevalence estimatesEuropean Respiratory Journal, 2006
- Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveysThe Lancet, 2006
- Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveysJournal of Allergy and Clinical Immunology, 2004
- Asthma control in the Asia-Pacific region: The asthma insights and reality in Asia-Pacific studyJournal of Allergy and Clinical Immunology, 2003
- Worldwide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC)European Respiratory Journal, 1998
- Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAACThe Lancet, 1998
- Comparison of the ISAAC video questionnaire (AVQ 3.0) with the ISAAC written questionnaire for estimating asthma associated with bronchial hyperreactivityClinical & Experimental Allergy, 1997
- International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methodsEuropean Respiratory Journal, 1995