Sizing up sialic acid in glomerular disease
Open Access
- 1 June 2007
- journal article
- editorial
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 117 (6), 1480-1483
- https://doi.org/10.1172/jci32482
Abstract
A new study by Galeano and colleagues in this issue of the JCI reports the first glomerular disease caused by a genetic defect in sialic acid biosynthesis (see the related article beginning on page 1585). Mice that harbor mutations in the Gne/Mnk gene produce lower amounts of sialic acid, suffer from hematuria, proteinuria, and structural defects in the glomerulus and die within days after birth. Remarkably, the lesion can be reversed through dietary addition of N-acetylmannosamine, a sialic acid precursor, raising the intriguing possibility that this approach might have therapeutic benefit in patients with glomerular disease.Keywords
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