Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities
- 10 September 2012
- journal article
- review article
- Published by Wiley in The FASEB Journal
- Vol. 26 (12), 4788-4804
- https://doi.org/10.1096/fj.12-216663
Abstract
Recent reviews have focused on the structure and function of histone chaperones involved in different aspects of somatic cell chromatin metabolism. One of the most dramatic chromatin remodeling processes takes place immediately after fertilization and is mediated by egg histone storage chaperones. These include members of the nucleoplasmin (NPM2/NPM3), which are preferentially associated with histones H2A-H2B in the egg and the nuclear autoantigenic sperm protein (NASP) families. Interestingly, in addition to binding and providing storage to H3/H4 in the egg and in somatic cells, NASP has been shown to be a unique genuine chaperone for histone H1. This review revolves around the structural and functional roles of these two families of chaperones whose activity is modulated by their own post-translational modifications (PTMs), particularly phosphorylation. Beyond their important role in the remodeling of paternal chromatin in the early stages of embryogenesis, NPM and NASP members can interact with a plethora of proteins in addition to histones in somatic cells and play a critical role in processes of functional cell alteration, such as in cancer. Despite their common presence in the egg, these two histone chaperones appear to be evolutionarily unrelated. In contrast to members of the NPM family, which share a common monophyletic evolutionary origin, the different types of NASP appear to have evolved recurrently within different taxa.—Finn, R. M., Ellard, K., Eirín-López, J. M., Ausió, J. Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities.Keywords
This publication has 98 references indexed in Scilit:
- Histone chaperones link histone nuclear import and chromatin assemblyBiochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012
- The role of FACT in making and breaking nucleosomesBiochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012
- A Specific Function for the Histone Chaperone NASP to Fine-Tune a Reservoir of Soluble H3-H4 in the Histone Supply ChainMolecular Cell, 2011
- A Tissue-Specific Atlas of Mouse Protein Phosphorylation and ExpressionCell, 2010
- yFACT Induces Global Accessibility of Nucleosomal DNA without H2A-H2B DisplacementMolecular Cell, 2009
- Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entityHematological Oncology, 2009
- A NASP (N1/N2)-Related Protein, Sim3, Binds CENP-A and Is Required for Its Deposition at Fission Yeast CentromeresMolecular Cell, 2007
- Chromatin Challenges during DNA Replication and RepairCell, 2007
- PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylationProteomics, 2004
- A Rad53 Kinase-Dependent Surveillance Mechanism that Regulates Histone Protein Levels in S. cerevisiaeCell, 2003