GPR15-Mediated Homing Controls Immune Homeostasis in the Large Intestine Mucosa
- 21 June 2013
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 340 (6139), 1456-1459
- https://doi.org/10.1126/science.1237013
Abstract
GPR15 Gets Tregsto Guard the Gut: The large intestine is the site that is typically most inflamed in Crohn's disease and ulcerative colitis, which are thought to result when the immune system is not able to keep the peace with trillions of resident gut microbes. The immune system does this by recruiting specific cell populations, like regulatory T cells (Tregs), to the gut.Kimet al.(p.1456, published online 9 May) now suggest that the orphan G protein–coupled receptor GPR15 is expressed by Tregsand required for Treghoming to the large intestine in mice.Keywords
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