Impact of Metabolic Syndrome on the Development of Cardiovascular Disease in a General Japanese Population
- 1 July 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 38 (7), 2063-2069
- https://doi.org/10.1161/strokeaha.106.479642
Abstract
Background and Purpose— The metabolic syndrome (MetS) is associated with an increased risk of cardiovascular disease (CVD) events in general populations. However, well-designed prospective studies in Asian populations are very limited. Methods— We prospectively evaluated a total of 2452 community-dwelling Japanese individuals aged 40 years or older from 1988 to 2002 and examined the effects of MetS defined by the modified National Cholesterol Education Program Adult Treatment Panel III criteria on incident CVD. Results— The prevalence of the MetS was 21% in men and 30% in women at baseline. During the follow up, 307 CVD events occurred. Compared with those without MetS, the age-adjusted incidence of CVD (per 1000 person-years) was significantly higher in subjects with the MetS in both men (21.8 versus 11.6, P P Conclusions— Our findings suggest that MetS is a significant risk factor for the development of CVD in the Japanese middle-aged population.Keywords
This publication has 33 references indexed in Scilit:
- Metabolic syndrome—a new world‐wide definition. A Consensus Statement from the International Diabetes FederationDiabetic Medicine, 2006
- Influence of Metabolic Syndrome and General Obesity on the Risk of Ischemic StrokeStroke, 2006
- The New Worldwide Definition of Metabolic Syndrome Is Not a Better Diagnostic Predictor of Cardiovascular Disease in Japanese Diabetic Patients Than the Existing DefinitionsDiabetes Care, 2006
- C-Reactive Protein, the Metabolic Syndrome, and Prediction of Cardiovascular Events in the Framingham Offspring StudyCirculation, 2004
- Prevalence of the Metabolic Syndrome and Its Relation to All-Cause and Cardiovascular Mortality in Nondiabetic European Men and WomenArchives of Internal Medicine, 2004
- The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality StudyAtherosclerosis, 2004
- Trends in the Incidence, Mortality, and Survival Rate of Cardiovascular Disease in a Japanese CommunityStroke, 2003
- Global and societal implications of the diabetes epidemicNature, 2001
- Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)JAMA, 2001
- Prevalence of Type 2 (non-insulin-dependent) diabetes mellitus and impaired glucose tolerance in the Japanese general population: the Hisayama studyDiabetologia, 1993