High doses of oxycodone–naloxone combination may provide poor analgesia
- 9 June 2011
- journal article
- case report
- Published by Springer Science and Business Media LLC in Supportive Care in Cancer
- Vol. 19 (9), 1471-1472
- https://doi.org/10.1007/s00520-011-1205-x
Abstract
Several studies have shown that an oxycodone/naloxone combination (ratio 2:1) provides analgesia and less constipation in non-cancer patients receiving relatively low doses of this formulation. A case report of a cancer patient who was receiving increasing doses of oxycodone with an unexpected declining analgesia is presented. The substitution with the same doses (240 mg/day) of regular controlled-release oxycodone was effective in regaining adequate analgesia.Keywords
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