Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity
Open Access
- 1 March 1999
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 126 (6), 1393-1407
- https://doi.org/10.1038/sj.bjp.0702453
Abstract
Bioactivation of sulphamethoxazole (SMX) to chemically-reactive metabolites and subsequent protein conjugation is thought to be involved in SMX hypersensitivity. We have therefore examined the cel...Keywords
This publication has 72 references indexed in Scilit:
- Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV-infected patientsAIDS, 1997
- HIV-related skin diseasesThe Lancet, 1996
- Decreased release of glutathione into the systemic circulation of patients with HIV infectionEuropean Journal of Clinical Investigation, 1996
- Investigations of Glutathione Conjugation in Vitro by 1H NMR Spectroscopy. Uncatalyzed and Glutathione Transferase-Catalyzed ReactionsChemical Research in Toxicology, 1995
- Immunochemical analysis of sulfonamide drug allergy: Identification of sulfamethoxazole-substituted human serum proteinsJournal of Allergy and Clinical Immunology, 1994
- Polycyclic aromatic hydrocarbon (PAH) ortho-quinone conjugate chemistry: Kinetics of thiol addition to PAH ortho-quinones and structures of thioether adducts of naphthalene-1,2-dioneChemico-Biological Interactions, 1992
- Drug-induced toxic epidermal necrolysis (Lyell syndrome) in patients infected with the human immunodeficiency virusJournal of the American Academy of Dermatology, 1992
- Reactions of nitrosonitrobenzenes with biological thiols: Identification and reactivity of glutathion-S-yl conjugatesChemico-Biological Interactions, 1992
- The Role of Leukocyte-Generated Reactive Metabolites in the Pathogenesis of Ideosyncratic Drug ReactionsDrug Metabolism Reviews, 1992
- Formation of 20-oxoleukotriene B4 by an alcohol dehydrogenase isolated from human neutrophilsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990