The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase
- 1 October 2006
- journal article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry
- Vol. 14 (19), 6586-6592
- https://doi.org/10.1016/j.bmc.2006.06.005
Abstract
No abstract availableKeywords
This publication has 26 references indexed in Scilit:
- A review of melanocortin receptor small molecule ligandsPeptides, 2005
- EPOXIDE HYDROLASES: Mechanisms, Inhibitor Designs, and Biological RolesAnnual Review of Pharmacology and Toxicology, 2005
- Optimization of Amide-Based Inhibitors of Soluble Epoxide Hydrolase with Improved Water SolubilityJournal of Medicinal Chemistry, 2005
- Epoxide hydrolases: their roles and interactions with lipid metabolismProgress in Lipid Research, 2005
- Design, Synthesis, and Biological Activity of 1,3-Disubstituted Ureas as Potent Inhibitors of the Soluble Epoxide Hydrolase of Increased Water SolubilityJournal of Medicinal Chemistry, 2004
- Binding of Alkylurea Inhibitors to Epoxide Hydrolase Implicates Active Site Tyrosines in Substrate ActivationJournal of Biological Chemistry, 2000
- Synthesis of (Glu34)human splenin(hSP) and examination of its immunological effect on the reduced B-lymphocytes of uremic patients.CHEMICAL & PHARMACEUTICAL BULLETIN, 1989
- Water solubility and octanol/water partition coefficients of organics. Limitations of the solubility-partition coefficient correlationEnvironmental Science & Technology, 1980
- Identification of the Bitter Principle of CocoaHelvetica Chimica Acta, 1975
- Selective reductions. XVIII. Fast reaction of primary, secondary, and tertiary amides with diborane. Simple, convenient procedure for the conversion of amides to the corresponding aminesThe Journal of Organic Chemistry, 1973