Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer
- 26 September 2014
- journal article
- Published by Spandidos Publications in Oncology Reports
- Vol. 32 (6), 2485-2492
- https://doi.org/10.3892/or.2014.3518
Abstract
Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) correlate with several solid tumors. However, the underlying molecular mechanisms and its clinical significance in pancreatic cancer remain to be elucidated. In the present study, our results showed that MALAT-1 expression levels were upregulated in pancreatic cancer tissues compared with adjacent noncancerous controls. Consistently, higher expression level of MALAT-1 was found in all seven pancreatic cancer cell lines relative to the human pancreatic ductal epithelial cell. Further function analysis revealed that downregulation of MALAT-1 could inhibit tumor cell proliferation and decrease cell migration and invasion in vitro. The underlying mechanisms are possibly involved in inducing G2/M cell cycle arrest, promoting cell apoptosis, suppressing epithelial-mesenchymal transition and reducing cancer stem-like properties. In conclusion, this study indicated that MALAT-1 may serve as an oncogenic lncRNA that is involved in malignancy phenotypes of pancreatic cancer. Therefore, it may be used as a potential therapeutic target.Keywords
This publication has 18 references indexed in Scilit:
- Long noncoding RNAs: Novel insights into hepatocelluar carcinomaCancer Letters, 2014
- Bithionol inhibits ovarian cancer cell growth In Vitro- studies on mechanism(s) of actionBMC Cancer, 2014
- MALAT1 — a paradigm for long noncoding RNA function in cancerJournal of Molecular Medicine, 2013
- High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)–mediated inhibition of platelet productionBlood, 2012
- Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress‐independent growth inhibition of pancreatic cancer cells through G2/M cell‐cycle arrest and apoptosisCancer Science, 2010
- Pancreatic Cancer Stem CellsJournal of Clinical Oncology, 2008
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem CellsCell, 2008
- NF‐κB and epithelial to mesenchymal transition of cancerJournal of Cellular Biochemistry, 2008
- Control of the G2/M TransitionMolecular Biotechnology, 2006
- MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancerOncogene, 2003