High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active Against Multi-drug-resistant Clinical Strains
- 1 April 2004
- journal article
- Published by Elsevier BV in Journal of Molecular Biology
- Vol. 338 (2), 341-352
- https://doi.org/10.1016/j.jmb.2004.02.052
Abstract
No abstract availableKeywords
This publication has 33 references indexed in Scilit:
- Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights for Better Antiviral TherapyJournal of Virology, 2003
- Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 ProteaseJournal of Virology, 2002
- Structural and kinetic analysis of drug resistant mutants of HIV‐1 proteaseEuropean Journal of Biochemistry, 1999
- Drug resistance mutations can affect dimer stability of HIV-1 protease at neutral pHProtein Science, 1999
- Resistance to HIV Protease Inhibitors: A Comparison of Enzyme Inhibition and Antiviral PotencyBiochemistry, 1998
- Crystallographic Analysis of Human Immunodeficiency Virus 1 Protease with an Analog of the Conserved CA‐p2 SubstrateEuropean Journal of Biochemistry, 1997
- [20] Processing of X-ray diffraction data collected in oscillation modeMethods in Enzymology, 1997
- Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological EvaluationJournal of Medicinal Chemistry, 1996
- MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresJournal of Applied Crystallography, 1991
- Inhibition of porcine pepsin by two substrate analogs containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinasesJournal of Medicinal Chemistry, 1988