Travoprost
- 1 January 2002
- journal article
- review article
- Published by Springer Science and Business Media LLC in Drugs & Aging
- Vol. 19 (6), 465-471
- https://doi.org/10.2165/00002512-200219060-00005
Abstract
▲ Travoprost is a synthetic ester prodrug of a prostaglandin F2α analogue used in the treatment of open-angle glaucoma and ocular hypertension. ▲ Intraocular travoprost 0.004% once daily was significantly more effective at reducing intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension than placebo or timolol 0.5% twice daily and was at least as effective as latanoprost 0.005% once daily in randomised, double-blind studies. ▲ When used as adjunctive therapy with timolol 0.5% twice daily in patients with elevated IOP not adequately controlled by timolol alone, travoprost 0.004% showed significant additional IOP reduction in a randomised double-blind trial. ▲ Travoprost 0.004% was well tolerated in clinical trials. The majority of adverse events such as ocular hyperaemia and eyelash changes were mild and resolved without treatment. ▲ Travoprost is a synthetic ester prodrug of a prostaglandin F2α analogue used in the treatment of open-angle glaucoma and ocular hypertension. ▲ Intraocular travoprost 0.004% once daily was significantly more effective at reducing intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension than placebo or timolol 0.5% twice daily and was at least as effective as latanoprost 0.005% once daily in randomised, double-blind studies. ▲ When used as adjunctive therapy with timolol 0.5% twice daily in patients with elevated IOP not adequately controlled by timolol alone, travoprost 0.004% showed significant additional IOP reduction in a randomised double-blind trial. ▲ Travoprost 0.004% was well tolerated in clinical trials. The majority of adverse events such as ocular hyperaemia and eyelash changes were mild and resolved without treatment.Keywords
This publication has 14 references indexed in Scilit:
- Evaluation of travoprost as adjunctive therapy in patients with uncontrolled intraocular pressure while using timolol 0.5%American Journal of Ophthalmology, 2001
- Travoprost compared with latanoprost and timolol in patients with open-angle glaucoma or ocular hypertensionAmerican Journal of Ophthalmology, 2001
- Comparison of Topical Travoprost Eye Drops Given Once Daily and Timolol 0.5% Given Twice Daily in Patients with Open-Angle Glaucoma or Ocular HypertensionJournal of Glaucoma, 2001
- Preclinical Efficacy of Travoprost, a Potent and Selective FP Prostaglandin Receptor AgonistJournal of Ocular Pharmacology and Therapeutics, 2001
- Pharmacological characterization of [3H]‐prostaglandin E2 binding to the cloned human EP4 prostanoid receptorBritish Journal of Pharmacology, 2000
- [3H]AL-5848 ([3H]9β-(+)-Fluprostenol). Carboxylic Acid of Travoprost (AL-6221), a Novel FP Prostaglandin o study the Pharmacology and Autoradiographic Localization of the FP ReceptorJournal of Pharmacy and Pharmacology, 1999
- Prostaglandin Analogues in the Treatment of GlaucomaDrugs & Aging, 1999
- Medical Management of GlaucomaThe New England Journal of Medicine, 1998
- Systemic Adverse Effects of Topical Ophthalmic AgentsDrugs & Aging, 1997
- Glaucoma therapy may take your breath awayAge and Ageing, 1997