Polymorphisms of ACE2 are Associated with Blood Pressure Response to Cold Pressor Test: The GenSalt Study
Open Access
- 31 May 2012
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Hypertension
- Vol. 25 (8), 937-942
- https://doi.org/10.1038/ajh.2012.61
Abstract
Increased blood pressure (BP) reactivity to cold pressor test (CPT) is a risk factor for hypertension. Genetic factors may influence the variation of BP response to CPT among individuals. We explored the association of genetic variants in the apelin system genes (APLN, APLNR and ACE2) and BP response to CPT in a Chinese population. A total of 1,998 Han Chinese participants from the Genetic Epidemiology Network of Salt Sensitivity completed a CPT. The percentage changes of BP right after the end of ice-water immersion were used as the measurement of BP responses to CPT. Twenty-two single nucleotide polymorphisms (SNPs) were selected and genotyped, including both tag and potential functional SNPs of the APLN, APLNR, and ACE2 genes. A mixed-effect linear model was used to assess the association between SNPs and BP responses to CPT. In women, three SNPs (rs1514283, rs4646176, and rs879922) of the ACE2 gene were significantly associated with the diastolic BP (DBP) response to CPT in the general and recessive genetic models after adjustment for multiple testing (all false discovery rate q < 0.05). There were no significant associations of polymorphisms in APLN and APLNR genes with BP responses to CPT. Our study identified genetic variants in the ACE2 gene that were significantly associated with DBP responses to cold stress in the Chinese female population. Future studies are warranted to confirm these findings. American Journal of Hypertension, advance online publication 31 May 2012; doi:10.1038/ajh.2012.61Keywords
This publication has 33 references indexed in Scilit:
- Genetic influences on cardiovascular stress reactivityNeuroscience & Biobehavioral Reviews, 2010
- Association of Genetic Variants in the Apelin-APJ System and ACE2 With Blood Pressure Responses to Potassium Supplementation: The GenSalt StudyAmerican Journal of Hypertension, 2010
- Genetic variants in the apelin system and blood pressure responses to dietary sodium interventions: a family-based association studyJournal of Hypertension, 2010
- Heritability of Blood Pressure Responses to Cold Pressor Test in a Chinese PopulationAmerican Journal of Hypertension, 2009
- Apelin Gene Transfer Into the Rostral Ventrolateral Medulla Induces Chronic Blood Pressure Elevation in Normotensive RatsCirculation Research, 2009
- Association Between Blood Pressure Responses to the Cold Pressor Test and Dietary Sodium Intervention in a Chinese PopulationJAMA Internal Medicine, 2008
- Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart StudyJournal of Hypertension, 2008
- PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics, 2007
- GenSalt: rationale, design, methods and baseline characteristics of study participantsJournal of Human Hypertension, 2007
- Genetic influences on blood pressure with the cold-pressor test: a twin studyJournal Of Hypertension, 1996