Further studies on the therapeutic effect of indomethacin on esophageal tumors

Abstract

The effect of treatment with the nonsteroid anti‐inflammatory drug indomethacin, was investigated in 250 3‐month‐old C57B1 female mice following induction of esophageal tumors with diethylnitrosamine (DEN). Already 3 months after DEN treatment, many esophageal tumors were committed to occur: despite discontinued DEN treatment, the number of tumors had increased significantly at 6 or 9 months of observation. Following 3 and 4 months of DEN administration, the development of many already committed esophageal tumors was significantly abrogated by treating the mice with indomethacin. Cancer 58:1029‐1031, 1986.