Replication protein A: directing traffic at the intersection of replication and repair
- 1 January 2010
- journal article
- review article
- Published by IMR Press in Frontiers in Bioscience-Landmark
- Vol. 15 (1), 883-900
- https://doi.org/10.2741/3652
Abstract
Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.Keywords
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