Applications of post-translational modifications of FoxO family proteins in biological functions
Open Access
- 13 June 2011
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Molecular Cell Biology
- Vol. 3 (5), 276-282
- https://doi.org/10.1093/jmcb/mjr013
Abstract
The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FoxO family proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases.Keywords
This publication has 77 references indexed in Scilit:
- Abelson Virus Transformation Prevents TRAIL Expression by Inhibiting FoxO3a and NF-κBMolecules and Cells, 2010
- SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic ratsProceedings of the National Academy of Sciences of the United States of America, 2009
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activityNature, 2009
- OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteinsTrends in Molecular Medicine, 2008
- ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradationNature, 2008
- SIRT2 Regulates Adipocyte Differentiation through FoxO1 Acetylation/DeacetylationCell Metabolism, 2007
- FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell HomeostasisCell, 2007
- A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life SpanCell, 2006
- JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin SignalingCell, 2005
- A C. elegans mutant that lives twice as long as wild typeNature, 1993