Telomere length in myelodysplastic syndromes
- 3 June 2011
- journal article
- Published by Taylor & Francis Ltd in Leukemia & Lymphoma
- Vol. 52 (8), 1528-1536
- https://doi.org/10.3109/10428194.2011.568648
Abstract
The relationship between telomere length (TL) and predisposition to myelodysplastic syndromes (MDS) remains unclear. We compared peripheral blood leukocyte (PBL) TL among cases of histologically confirmed MDS (n = 65) who were treatment-naive with no prior cancer history to age-matched controls (n = 63). Relative TL was measured in PBLs and saliva by quantitative polymerase chain reaction (PCR) and in CD15+ and CD19+ cells by flow cytometry-fluorescence in situ hybridization (flow-FISH). Human telomerase reverse transcriptase gene (hTERT) mutations were assessed by PCR. After adjustment for age and sex, relative TLs were reduced in PBLs (p = 0.02), CD15+ (p = 0.01), CD19+ (p = 0.25), and saliva (p = 0.13) in MDS cases versus controls, although only the PBL and CD15+ results were statistically significant. Among MDS cases, CD15+ and CD19+ cell TLs were positively correlated (p = 0.03). PBL TL was reduced among those occupationally exposed to paints and pesticides, but was not associated with hTERT genotype. Future studies are needed to further investigate constitutional telomere attrition as a possible predisposing factor for MDS.This publication has 38 references indexed in Scilit:
- Leukocyte telomere length in a population-based case–control study of ovarian cancer: a pilot studyCancer Causes & Control, 2009
- Accelerated Telomere Shortening Precedes Development of Therapy-Related Myelodysplasia or Acute Myelogenous Leukemia After Autologous Transplantation for LymphomaJournal of Clinical Oncology, 2009
- Telomeres and marrow failureHematology, 2009
- The Extent and Significance of Telomere Loss with AgeAnnals of the New York Academy of Sciences, 2004
- Telomere Dysfunction: A Potential Cancer Predisposition FactorJNCI Journal of the National Cancer Institute, 2003
- Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndromeBlood, 2003
- Association between telomere length in blood and mortality in people aged 60 years or olderThe Lancet, 2003
- The World Health Organization (WHO) classification of the myeloid neoplasmsBlood, 2002
- Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometryBlood, 2000
- Myeloid leukemias and myelodysplastic syndromes: chemical exposure, histologic subtype and cytogenetics in a case-control studyCancer Genetics and Cytogenetics, 1993