Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study
Open Access
- 30 July 2009
- journal article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 35 (3), 540-548
- https://doi.org/10.1183/09031936.00088209
Abstract
Chronic obstructive pulmonary disease (COPD) is considered an inflammatory pulmonary disorder with systemic inflammatory manifestations. The aim of this study was to assess the systemic levels of six inflammatory mediators in a large cohort of COPD patients and controls. 409 COPD patients and 231 healthy subjects, aged 40–75 yrs, were included from the first phase of the Bergen COPD Cohort Study. All COPD patients were clinically diagnosed by a physician, and had a forced expiratory volume in 1 s/forced vital capacity ratio less than 0.7 and a smoking history of >10 pack-yrs. The plasma levels of C-reactive protein (CRP), soluble tumour necrosis factor receptor (sTNFR)-1, osteoprotegrin, neutrophil activating peptide-2, CXCL16 and monocyte chemoattractant protein-4 were determined by ELISA. After adjustment for all known confounders, COPD patients had significantly lower levels of osteoprotegrin than subjects without COPD (p<0.05), and higher levels of CRP (p<0.01). Among COPD patients, CRP was elevated in patients with frequent exacerbations (p<0.05). sTNFR-1 and osteoprotegrin were both related to Global Initiative for Chronic Obstructive Lung Disease stage and frequency of exacerbations in the last 12 months (p<0.05). In addition, sTNFR-1 was significantly associated with important comorbidities such as hypertension and depression (p<0.05). The present study confirms that certain circulating inflammatory mediators are an important phenotypic feature of COPD.This publication has 37 references indexed in Scilit:
- IL6 and CRPhaplotypes are associated with COPD risk and systemic inflammation: a case-control studyBMC Medical Genetics, 2009
- Increased Serum Inflammatory Markers in the Absence of Clinical and Skeletal Muscle Inflammation in Patients with Chronic Obstructive Pulmonary DiseaseRespiration, 2009
- The cytokine network in asthma and chronic obstructive pulmonary diseaseJCI Insight, 2008
- Prevalence and Risk Factors for Depressive Symptoms in Persons with Chronic Obstructive Pulmonary DiseaseJournal of General Internal Medicine, 2008
- Possible mechanisms underlying the development of cachexia in COPDEuropean Respiratory Journal, 2008
- Effects of TNF-α and Leptin on Weight Loss in Patients with Stable Chronic Obstructive Pulmonary DiseaseThe Korean Journal of Internal Medicine, 2007
- Inflammatory cells in the airways in COPDThorax, 2006
- Enhanced T-Cell Expression of RANK Ligand in Acute Coronary SyndromeArteriosclerosis, Thrombosis, and Vascular Biology, 2006
- Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjectsThorax, 2005
- The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary DiseaseThe New England Journal of Medicine, 2004