Prevalence of allergic symptoms among children with diabetes mellitus type 1 of different socioeconomic status
- 1 August 2008
- journal article
- research article
- Published by Hindawi Limited in Pediatric Diabetes
- Vol. 9 (4pt2), 407-416
- https://doi.org/10.1111/j.1399-5448.2008.00444.x
Abstract
The aim of the study was to assess the possible associations between allergies and type 1 diabetes mellitus (DM1), stratified by social class. We studied 127 children with DM1 with a median age of 10.8 yr and 150 controls of comparable age and sex distribution. The parents completed questionnaires on their education and occupation and on their children's history of allergic symptoms, breast-feeding, viral infections, and measles-mumps-rubella (MMR) vaccination. Lower family's social class was more frequently encountered among the DM1 families than in the controls (OR = 0.56, 95% CI: 0.35-0.92). The occurrence of any allergic symptoms among children with DM1 (35.45%) was not significantly different from the controls (38.78%), neither in the total group (OR = 0.87, 95% CI: 0.52-1.45) nor in the stratified analysis by social class. Similar findings were observed regarding the different types of allergic symptoms. In the univariate analysis, breast-feeding, the experience of viral infections, and MMR vaccination were found to be protective of DM1 presentation in both upper and lower social classes. In the multiple logistic regression analysis, the experience of more than 2 infections/yr (OR = 0.12, 95% CI: 0.04-0.34), the origin from middle and upper social classes (OR = 0.42, 95% CI: 0.22-0.80) and breast-feeding (OR = 0.58, 95% CI: 0.31-1.07) were protective of DM1 occurrence. In children with DM1, the presence of allergic symptoms was not associated with the development of DM1. Among the environmental factors, the origin from middle or upper social classes, breast-feeding, the experience of viral infections, and MMR vaccination were found to have a protective effect on DM1 presentation.Keywords
This publication has 48 references indexed in Scilit:
- Psychological Stress May Induce Diabetes-Related Autoimmunity in InfancyDiabetes Care, 2005
- Early Nutrition and Later Diabetes RiskAdvances in experimental medicine and biology, 2004
- A Meta-Analysis of the Association Between Childhood Type 1 Diabetes and Atopic DiseaseDiabetes Care, 2003
- Atopic eczema in early childhood could be protective against Type 1 diabetesDiabetologia, 2003
- Predisposition to Atopic Symptoms to Inhaled Antigens May Protect From Childhood Type 1 DiabetesDiabetes Care, 2002
- Common risk factors in type 1 diabetes and asthmaThe Lancet, 2001
- Atopy, autoimmunity, and the TH1/TH2 balanceThe Journal of Pediatrics, 2000
- Influence of maternal age at delivery and birth order on risk of type 1 diabetes in childhood: prospective population based family studyBMJ, 2000
- Children with type-1 diabetes and their unaffected siblings have few er symptoms of asthmaThe Lancet, 1999
- Increasing incidence of IDDM a consequence of improved hygiene?Diabetologia, 1994