The Ena/VASP enigma
- 15 December 2002
- journal article
- review article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 115 (24), 4721-4726
- https://doi.org/10.1242/jcs.00218
Abstract
Ena/VASP proteins are actin-binding proteins that localize to actin stress fibres, the tips of filopodia and the lamellipodial leading edge. In the past few years, a number of seemingly conflicting studies have confused the Ena/VASP field, pointing to roles for these proteins in both promotion and inhibition of actin-dependent processes. Recent discoveries resolve these contradictions and suggest a novel mechanism of Ena/VASP function, in which the proteins function as 'anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments.Keywords
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