Ethnicity and Difference in Dengue Virus-Specific Memory T Cell Responses in Cuban Individuals
- 1 December 2006
- journal article
- research article
- Published by Mary Ann Liebert Inc in Viral Immunology
- Vol. 19 (4), 662-668
- https://doi.org/10.1089/vim.2006.19.662
Abstract
The different risk factors associated with dengue hemorrhagic fever pathogenesis needs yet additional clarification. The exceptional epidemiological circumstances in Cuba allow their evaluation in a well-defined situation. In the present study the memory T cell response of 80 Cuban donors previously infected with dengue-1 and dengue-2 during the 1977 and 1981 epidemics, and belonging to different ethnic groups, was examined. White people showed, in contrast to black people, stronger and remarkably cross-reactive dengue virus-specific memory CD4+ T lymphocyte proliferation and interferon-γ release. The observed variation in T cell response according to ethnicity could be related to the immunopathogenesis of dengue hemorrhagic fever, and may partially explain the epidemiological evidence that black individuals are at lower risk for the most severe dengue clinical course compared with white individuals.Keywords
This publication has 20 references indexed in Scilit:
- Altered Cytokine Responses of Dengue-Specific CD4+ T Cells to Heterologous SerotypesPublished by The American Association of Immunologists ,2005
- Dengue 3 Epidemic, Havana, 2001Emerging Infectious Diseases, 2004
- La epidemiología del dengue y del dengue hemorrágico en Santiago de Cuba, 1997Revista Panamericana de Salud Pública, 1999
- Immunopathogenesis of Dengue Hemorrhagic FeverVirology, 1999
- Reemergence of dengue in Cuba: a 1997 epidemic in Santiago de Cuba.Emerging Infectious Diseases, 1998
- Dengue Virus-Specific Memory T Cell Responses in Human Volunteers Receiving a Live Attenuated Dengue Virus Type 2 Candidate VaccineThe Journal of Infectious Diseases, 1994
- Dengue virus-specific human T cell clones. Serotype crossreactive proliferation, interferon gamma production, and cytotoxic activity.The Journal of Experimental Medicine, 1989
- Why dengue haemorrhagic fever in Cuba? 2. An integral analysisTransactions of the Royal Society of Tropical Medicine and Hygiene, 1987
- Why dengue haemorrhagic fever in Cuba? I. Individual risk factors for dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS)Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987
- The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel FiltrationScandinavian Journal of Clinical and Laboratory Investigation, 1968