A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major
- 1 January 2008
- journal article
- Published by Ferrata Storti Foundation (Haematologica) in Haematologica
- Vol. 93 (1), 116-119
- https://doi.org/10.3324/haematol.11768
Abstract
We studied the utility of pancreatic magnetic resonance imaging (MRI) in 72 thalassemia major patients (21 diabetic, 51 normoglycemic). Diabetic patients were significantly older (pp<0.0001). The two groups were comparable for ferritin and MRI-T2* heart, liver and pancreas. Pancreatic T2* signals were abnormal in 80% of both groups, and correlated with heart T2*. In normoglycemic patients, cardiac T2* and log-pancreatic T2* values correlated with homeostatic model assessments HOMA-B (β cell reserve), HOMA-IR (insulin resistance) and fasting insulin/C-peptide levels. This suggested that improved chelation may improve β cell reserve and prevent pancreatic atrophy.Keywords
This publication has 13 references indexed in Scilit:
- Magnetic resonance imaging: a reliable method for measuring pancreatic volume in Type 1 diabetesDiabetic Medicine, 2007
- Cardiac magnetic resonance imaging R2* assessments and analysis of historical parameters in patients with transfusion-dependent thalassemia.Haematologica, 2007
- The pancreas in β-thalassemia major: MR imaging features and correlation with iron stores and glucose disturbuncesEuropean Radiology, 2006
- Reduced insulin secretion in normoglycaemic patients with β‐thalassaemia majorDiabetic Medicine, 2006
- Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosisBlood, 2006
- Failure of Mathematical Indices to Accurately Assess Insulin Resistance in Lean, Overweight, or Obese Women with Polycystic Ovary SyndromeJournal of Clinical Endocrinology & Metabolism, 2004
- Magnetic resonance screening of iron status in transfusion‐dependent β‐thalassaemia patientsBritish Journal of Haematology, 2004
- L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathyNature Medicine, 2003
- A single breath‐hold multiecho T2* cardiovascular magnetic resonance technique for diagnosis of myocardial iron overloadJournal of Magnetic Resonance Imaging, 2003
- MR imaging of pancreatic changes in patients with transfusion-dependent beta-thalassemia major.American Journal of Roentgenology, 1999