Dysregulated lipid metabolism in cancer
Open Access
- 1 January 2012
- journal article
- Published by Baishideng Publishing Group Inc. in World Journal of Biological Chemistry
- Vol. 3 (8), 167-74
- https://doi.org/10.4331/wjbc.v3.i8.167
Abstract
Alteration of lipid metabolism has been increasingly recognized as a hallmark of cancer cells. The changes of expression and activity of lipid metabolizing enzymes are directly regulated by the activity of oncogenic signals. The dependence of tumor cells on the dysregulated lipid metabolism suggests that proteins involved in this process are excellent chemotherapeutic targets for cancer treatment. There are currently several drugs under development or in clinical trials that are based on specifically targeting the altered lipid metabolic pathways in cancer cells. Further understanding of dysregulated lipid metabolism and its associated signaling pathways will help us to better design efficient cancer therapeutic strategy.Keywords
This publication has 79 references indexed in Scilit:
- The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor GenesScience, 2010
- De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid SaturationCancer Research, 2010
- Glutamine addiction: a new therapeutic target in cancerTrends in Biochemical Sciences, 2010
- Metabolism and proliferation share common regulatory pathways in cancer cellsOncogene, 2010
- Metabolic genes in cancer: Their roles in tumor progression and clinical implicationsBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2010
- Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant functionProceedings of the National Academy of Sciences of the United States of America, 2010
- Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen speciesProceedings of the National Academy of Sciences of the United States of America, 2010
- Targeting metabolic transformation for cancer therapyNature Reviews Cancer, 2010
- The Akt–SREBP nexus: cell signaling meets lipid metabolismTrends in Endocrinology & Metabolism, 2010
- Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer PathogenesisCell, 2010