Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic Approaches
Open Access
- 18 June 2012
- journal article
- review article
- Published by Hindawi Limited in Arthritis
- Vol. 2012, 1-8
- https://doi.org/10.1155/2012/741582
Abstract
It is increasingly recognized that the pathogenesis of cartilage degradation in osteoarthritis (OA) is multifactorial and involves the interactions between cartilage and its surrounding tissues. These interactions regulate proinflammatory cytokine-mediated cartilage destruction, contributing to OA progression as well as cartilage repair. This review explores the pathogenesis of OA in the context of the multiple tissue types in the joint and discusses the implications of such complex tissue interaction in the development of anti-inflammatory therapeutics for the treatment of OA.Keywords
This publication has 107 references indexed in Scilit:
- Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritisMagnetic Resonance Imaging, 2012
- Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imagingArthritis & Rheumatism, 2010
- Age‐associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRIJournal of Orthopaedic Research, 2010
- Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST studyOsteoarthritis and Cartilage, 2010
- Muscle cells enhance resistance to pro-inflammatory cytokine-induced cartilage destructionBiochemical and Biophysical Research Communications, 2010
- Synovial fibroblasts spread rheumatoid arthritis to unaffected jointsNature Medicine, 2009
- The role of muscle cells in regulating cartilage matrix productionJournal of Orthopaedic Research, 2009
- Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritisArthritis & Rheumatism, 2009
- Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pigInternational Journal of Experimental Pathology, 2009
- OsteoarthritisJournal of Cellular Physiology, 2007