Immunologic Aspects of Multiple Sclerosis
- 21 March 2011
- journal article
- review article
- Published by Wiley in Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine
- Vol. 78 (2), 207-220
- https://doi.org/10.1002/msj.20249
Abstract
Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system characterized by demyelination and axonal loss. Genetic and environmental factors contribute to the risk of immune dysregulation in multiple sclerosis. The review focuses on the immunopathogenic role played by various lymphocyte subsets and their cytokine products in the onset and disease progression, and the role of regulatory immune cells in disease remission. The mechanism of action of approved and experimental therapies, and how these mechanisms support the immunopathogenesis paradigm, is also reviewed. Mt Sinai J Med 78:207–220, 2011. © 2011 Mount Sinai School of MedicineKeywords
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