Chondroitin sulfate in the treatment of osteoarthritis: fromin vitrostudies to clinical recommendations
Open Access
- 4 October 2010
- journal article
- review article
- Published by SAGE Publications in Therapeutic Advances in Musculoskeletal Disease
- Vol. 2 (6), 335-348
- https://doi.org/10.1177/1759720x10383076
Abstract
Chondroitin sulfate (CS) is recommended as a therapeutic intervention in the multimodal approach of osteoarthritis (OA) management. CS has been studied extensively to describe its pharmacology (pharmacokinetic, in vitro and in vivo effects) and its clinical efficacy Various results have been reported depending on the system of evaluation (model, dosage an duration) and the source of CS (origin and quality). The purpose of this review was to gather most of the available information about CS and to discuss its potency in OA management.Keywords
This publication has 78 references indexed in Scilit:
- OARSI recommendations for the management of hip and knee osteoarthritis: Part III: changes in evidence following systematic cumulative update of research published through January 2009Osteoarthritis and Cartilage, 2010
- The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combinationOsteoarthritis and Cartilage, 2010
- Immunomodulatory and anti‐inflammatory effects of chondroitin sulphateJournal of Cellular and Molecular Medicine, 2009
- Influence of chondroitin sulfate on the biochemical, mechanical and frictional properties of cartilage explants in long-term cultureJournal of Biomechanics, 2009
- Chondroitin sulphate: A complex molecule with potential impacts on a wide range of biological systemsComplementary Therapies in Medicine, 2009
- The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: A report from the glucosamine/chondroitin arthritis intervention trialArthritis & Rheumatism, 2008
- OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelinesOsteoarthritis and Cartilage, 2008
- Natural chondroitin sulphates increase aggregation of proteoglycan complexes and decrease adamts-5 expression in interleukin 1 -treated chondrocytesAnnals Of The Rheumatic Diseases, 2007
- Effect of chondroitin sulphate in symptomatic knee osteoarthritis: a multicentre, randomised, double-blind, placebo-controlled studyAnnals Of The Rheumatic Diseases, 2007
- Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science studyArthritis Research & Therapy, 2007