Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation
- 1 February 2008
- journal article
- review article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 180 (3), 1309-1315
- https://doi.org/10.4049/jimmunol.180.3.1309
Abstract
Immune responses to infection are optimally designed to generate large numbers of effector T cells while simultaneously minimizing the collateral damage of their potentially lethal actions and generating memory T cells to protect against subsequent encounter with pathogens. Much remains to be discovered about how these equally essential processes are balanced to enhance health and longevity and, more specifically, what factors control effector T cell expansion, differentiation, and memory cell formation. The innate immune system plays a prominent role in the delicate balance of these decisions. Insights into these questions from recent work in the area of effector CD8 T cell differentiation will be discussed.Keywords
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