Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors
Open Access
- 1 January 2010
- journal article
- review article
- Published by Japan Endocrine Society in Endocrine Journal
- Vol. 57 (6), 467-475
- https://doi.org/10.1507/endocrj.k10e-095
Abstract
The present study summarized recent findings on roles of leptin and endocannabinoids as modulators of the peripheral components of sweet taste. The positive effect of endocannabinoids on sweet sensitivity was opposed to that of leptin which suppresses sweet sensitivity. Leptin and endocannabinoids, therefore, not only regulate food intake via central nervous systems but also may modulate palatability of foods by altering peripheral sweet taste responses via their cognate receptors. Orexigenic and anorexigenic factors such as endocannnabinoids and leptin may affect energy homeostasis by regulating taste sensitivity.Keywords
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